Separate vaults or subfolders for multi-topic research?

Source: https://x.com/cyrilxbt/status/2082304935547314254

#question#open#obsidian

The research-system article: if you would never want a query on one topic to

accidentally surface unrelated material, use separate vaults; if some

cross-pollination is valuable, use subfolders within one vault.

Our wiki uses topic subfolders under me/wiki. Open decision: is one vault with

subfolders enough, or do we split into separate vaults as the library grows?